Novel transdermal device for delivery of triamcinolone for nail psoriasis treatment
نویسندگان
چکیده
ABSTRACT Introduction: Nail psoriasis treatment is challenging due to difficult drug delivery and systemic therapy toxicities. Self-dissolvable microneedle patches embedded with corticosteroids offers a potentially rapid, minimally invasive platform good efficacy minimal adverse side effects. Methods: We conducted 4-month prospective randomised controlled trial. Subjects psoriatic nails were receive device delivered topical steroids on one hand control (topical Daivobet gel) the other. Two independent dermatologists blinded assignment scored their Psoriasis Severity Index (NAPSI) during visits at baseline, 2 4 months. All was discontinued after Average NAPSI score each analysed. Results: A total of 25 participants recruited, aged 22 73 years. Majority Chinese (72%), followed by Indian Malay. There equal randomisation left right nail. While there rapid significant improvement in average for arm months, had greater, more sustained The improved both group months compared baseline. However, only value controls baseline statistically (P=0.0039). No severe effects reported. Conclusion: To best our knowledge, this first trial comparing technology against conventional nail treatment. Our findings demonstrate as efficacious therapy. Keywords: Microneedle, nail,
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ژورنال
عنوان ژورنال: Annals Academy of Medicine Singapore
سال: 2022
ISSN: ['0304-4602']
DOI: https://doi.org/10.47102/annals-acadmedsg.2021380